How Obesity Causes Insulin Resistant

It is a well known fact that many people with obesity are at a high risk of developing insulin resistant. But, how does that happen. As you know obesity means excessive accumulation of fat. Fat tissues also act as an endocrine organ, so it secretes various types of chemicals. Leptin and resistin are two of such chemicals.These two chemicals have the ability to reduce the insulin sensitivity. Therefore, obese people become insulin resistant. When there is insulin resistance, the cells fail to uptake glucose from the circulation. As a result high blood glucose levels are seen in these people. Finally, they become diabetic.