Philadelphia chromosome is abnormal chromosome 22, which is created by reciprocal translational between the long arm of the chromosome 22 and the chromosome 9. How the translocation occurs is described in illustrations below.
The description of the resulting kryotype: t(9;22)(q34;q11)
This is a very famous chromosomal abnormality found in nearly 97% of the cases of chronic myeloid leukaemia. It is also found in the acute lymphocytic leukaemia especially when it occurs in the latter part of life.
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